Modification of WS2 nanosheets with beta-cyclodextrone and N-isopropylacrylamide polymers for tamoxifen adsorption and investigation of in vitro drug release

Autor: Maryam Daghighi Asli, Azar Bagheri Gh, Elham Moniri, Abbas Bohloli
Rok vydání: 2021
Předmět:
Zdroj: Research on Chemical Intermediates. 47:1955-1978
ISSN: 1568-5675
0922-6168
DOI: 10.1007/s11164-020-04376-5
Popis: In this research, tungsten disulfide (WS2) nanosheets were modified with beta-cyclodextrone (βCD) N-isopropylacrylamide polymers (NIPAAP) for adsorption of tamoxifen (TAM) drug. The synthesized WS2/βCD/NIPAAP samples were characterized by field-emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray diffraction (XRD) analyses. The adsorption experiments of TAM on WS2/βCD/NIPAAP were performed as a function of pH, reaction contact time, temperature and drug concentration. The adsorption kinetic data were well fitted to the pseudo-second-order model. Also, the equilibrium data were well described by Langmuir isotherm model. The maximum adsorption capacity of WS2/βCD/NIPAAP for TAM drug was found to be 62.0 mg/g. The results of regeneration tests showed that the synthesized WS2/βCD/NIPAAP adsorbent can be easily reused after 6 cycles of adsorption–desorption. Furthermore, TAM drug release was investigated in a simulated system with pH 7.4 at different temperatures. The results showed that the release of TAM drug from WS2/βCD/NIPAAP carrier at 50 °C and 37 °C was greater than TAM release at 25 °C. Also, the experimental data of drug release were studied by Higuchi, Ritger-Peppas, zero-order and first-order models. The release data were well fitted to the zero-order model indicating a case II transport. The results showed a high stability for TAM drug.
Databáze: OpenAIRE
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