Thermal-ionization isotope-dilution mass spectrometry as a definitive method for determination of potassium in serum

Autor:	L A Machlan, W R Kelly, K A Brletic, J W Gramlich
Rok vydání:	1982
Předmět:	Systematic error Chromatography Chemistry Potassium Biochemistry (medical) Clinical Biochemistry Analytical chemistry Thermal ionization chemistry.chemical_element Isotope dilution Mass spectrometry Characterization (materials science) Blood serum Ionization
Zdroj:	Clinical Chemistry. 28:1309-1313
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/28.6.1309
Popis:	Thermal-ionization isotope-dilution mass spectrometry is a highly precise and accurate method for the determination of potassium concentrations in serum. Although not suited for routine use because of the time and expense required, the technique provides an extremely valuable tool for the characterization of reference materials and for evaluating other analytical methods. The technique has recently been used to determine the concentration of potassium in a human serum standard, NBS Standard Reference Material 909. Seven vials of the serum were chemically processed and then analyzed by two spectroscopists independently, using different mass spectrometers. The results confirm previous work that indicates that a precision of 0.1% relative can be routinely achieved. The systematic errors in the method have been thoroughly evaluated. When the precise results are thus corrected, they are essentially bias free and hence definitive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6db1e011a139a767397787b1b526fe9 https://doi.org/10.1093/clinchem/28.6.1309 Zobrazit plný text záznamu