Combined experimental and mathematical modeling of macrophage driven left ventricle remodeling post MI
| Autor: | Gladys Patricia Escobar, Yufang Jin, J. Berger, Qiuxia Dai, Merry L. Lindsey |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
biology business.industry Transforming growth factor beta Matrix (biology) medicine.disease Extracellular matrix medicine.anatomical_structure Ventricle Internal medicine Heart failure Gene expression biology.protein Cardiology Medicine Myocardial infarction Osteopontin business |
| Zdroj: | 2008 International Conference on Machine Learning and Cybernetics. |
| DOI: | 10.1109/icmlc.2008.4621104 |
| Popis: | Biological complexity and limited quantitative measurements impose major challenges to standard engineering methodologies for modeling of biological pathways. A new approach is presented to describe the dynamics of the left ventricle (LV) remodeling process post myocardial infarction (MI) in terms of the experimental measurements. MI is a leading cause of congestive heart failure, and currently there is a lack of biomarkers to predict how the left ventricle (LV) will respond to injury. The objective of this study is to measure extracellular matrix (ECM) gene levels in the LV post-MI to identify candidate factors that are predictive of remodeling post MI. Left ventricle from unoperated control mice (n=6) and the remote and infarct regions from 7 day post-MI mice (n=7) were studied. Of the 84 genes evaluated, 51 were differentially expressed in the post-MI LV. Significantly up regulated genes included alpha1 collagen I and Spp1 (osteopontin; all pLt0.05). In the plasma, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and Spp1 (osteopontin) levels increased post-MI (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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