A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides

Autor:	Bernard R. Neustadt, Ahmad Fawzi, Ashit K. Ganguly, T. Nechuta, Elizabeth M. Smith, Hongtao Zhang, A. Wu
Rok vydání:	1995
Předmět:	Chemistry Endothelin receptor antagonist Organic Chemistry Clinical Biochemistry Drug Discovery Antagonist Pharmaceutical Science Molecular Medicine Pharmacology Molecular Biology Biochemistry
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:2041-2044
ISSN:	0960-894X
Popis:	Combinatorial libraries were constructed based on a hexapeptide endothelin receptor antagonist. Iterative optimization efficiently identified the most active member of the library and allowed preparation of a more potent antagonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6d06976cdcf1c4bf4efb47befcae6c4 https://doi.org/10.1016/0960-894x(95)00349-x Zobrazit plný text záznamu Full Text from ScienceDirect