Self-assembly of antifungal agent 5-fluorocytosine and nutrient trans-p-coumaric acid furnishes a cocrystal with the potential to reduce toxicity and side effects for the drug: a case study combining theory with experiment
Autor: | Fan-Zhi Bu, Yue-Ming Yu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li |
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Rok vydání: | 2023 |
Předmět: | |
Zdroj: | New Journal of Chemistry. 47:1328-1341 |
ISSN: | 1369-9261 1144-0546 |
Popis: | Cocrystallization of 5-fluorocytosine (FLCY) and trans-p-coumaric acid was first reported. Systematic studies combining theory with experiment revealed that both solubility and dissolution rate of FLCY can be down-regulated via cocrystallization. |
Databáze: | OpenAIRE |
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