Self-assembly of antifungal agent 5-fluorocytosine and nutrient trans-p-coumaric acid furnishes a cocrystal with the potential to reduce toxicity and side effects for the drug: a case study combining theory with experiment

Autor:	Fan-Zhi Bu, Yue-Ming Yu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li
Rok vydání:	2023
Předmět:	Materials Chemistry General Chemistry Catalysis
Zdroj:	New Journal of Chemistry. 47:1328-1341
ISSN:	1369-9261 1144-0546
Popis:	Cocrystallization of 5-fluorocytosine (FLCY) and trans-p-coumaric acid was first reported. Systematic studies combining theory with experiment revealed that both solubility and dissolution rate of FLCY can be down-regulated via cocrystallization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6c2a52f823d318835003fdef02c799a https://doi.org/10.1039/d2nj03622c Zobrazit plný text záznamu