A polymerase I palm in adenylyl cyclase?

Autor:	Arnold E. Ruoho, Yu Liu, Joël Janin, James H. Hurley, Tom Madej, Gongyi Zhang, Stephen H. Bryant
Rok vydání:	1997
Předmět:	chemistry.chemical_classification Multidisciplinary computer.file_format Biology Protein Data Bank DNA-binding protein Adenylyl cyclase chemistry.chemical_compound Crystallography chemistry biology.protein Nucleotide DNA polymerase I Structural motif computer
Zdroj:	Nature. 388:34-34
ISSN:	1476-4687 0028-0836
DOI:	10.1038/40313
Popis:	Bryant et al. reply — The adenylyl cyclase fold is a complex three-layer arrangement of α and β structures1 unlike any in the Brookhaven Protein Data Bank. Two simple and widely distributed motifs, the α/β roll11 and the double split βαβ (βαββαβ) sandwich11,12, occur as substructures (Fig. 2). The α/β roll comprises part of the inner two layers and the βαββαβ sandwich comprises part of the outer two layers. The substructures overlap, each forming part of the central β-sheet. The βαββαβ variant found in adenylyl cyclase has strand order 4-1-3-2, by far the most common12 (the third most common α+β structural motif in the Protein Data Bank11), occurring as a stand-alone domain structure in several nucleotide binding proteins and other unrelated proteins11,13.
Databáze:	OpenAIRE
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