New cationic photosensitizers: photophysical properties and results of preliminary studies of antibacterial efficacy
| Autor: | G. A. Meerovich, Yu. M. Romanova, Alekseeva Nv, Victor B. Loschenov, E.V. Akhlyustina, Evgeny A. Lukyanets, E. A. Makarova, I. G. Tiganova, I.D. Romanishkin, N. I. Philipova |
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| Rok vydání: | 2019 |
| Předmět: |
History
Aqueous solution biology Chemistry medicine.medical_treatment Cationic polymerization Photodynamic therapy Antimicrobial medicine.disease_cause biology.organism_classification Fluorescence Combinatorial chemistry Computer Science Applications Education Acinetobacter baumannii Staphylococcus aureus Amphiphile medicine |
| Zdroj: | Journal of Physics: Conference Series. 1189:012033 |
| ISSN: | 1742-6596 1742-6588 |
| Popis: | Polycationic derivatives of synthetic bacteriochlorin with absorption in the near infrared range are promising for the creation of photosensitizers (PS) for antimicrobial photodynamic therapy. In the present work, the photophysical and antibacterial properties of PS based on tetracationic derivatives of synthetic bacteriochlorins: hydrophilic 3-Py4BC(EtBr)4Br4 in aqueous solution and amphiphilic 3-Py4BCHP4Br4 in the dispersion of Kolliphor ELP were studied. Analysis of absorption and fluorescence in a wide range of concentrations has demonstrated low aggregation of the PS over the entire range. A high efficiency of photodynamic inactivation of Gram-positive Staphylococcus aureus and Gramnegative Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was observed. |
| Databáze: | OpenAIRE |
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