Synthese Simple des Analogues Fluores, Phosphones ou Sulfones de L'Acide Aspartique

Autor:	Colette Denier, Laurent Bijeire, Michel Mulliez, Waldir Tavares De Lima
Rok vydání:	2007
Předmět:	Cyanide Organic Chemistry chemistry.chemical_element Biochemistry Sulfur Inorganic Chemistry Acylation chemistry.chemical_compound chemistry Fluorine Moiety Organic chemistry Acid hydrolysis Trifluoroacetic anhydride Sodium sulfite
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 182:881-891
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500601087418
Popis:	Two stable hemiaminals, N acylated by the p-nitrobenzoyl or Boc group and each substituted by the difluorocarboxylethylester moiety, were obtained in a single step from the corresponding ethylhemiacetal. The Boc compound, after acylation by trifluoroacetic anhydride followed by in situ reaction either with trimethylsilylated derivatives of cyanide or diethylphosphite, or with sodium sulfite, led to the protected carboxylic, phosphonic, and sulfonic α-aminoacids, respectively. Acid hydrolysis, preceded by acidolysis in the cases of the sulfonic and phosphonic compounds, led to the free aminoacids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6b6b9af806212eb7f4f19b1f5345954 https://doi.org/10.1080/10426500601087418 Zobrazit plný text záznamu