Adherence to endocrine therapy in early breast cancer in relation to Cytochrome P450 2D6 genotype: a comparison between pharmacy dispensation data and medical records

Autor: Linda Thorén, Sara Margolin, Erik Eliasson, Jonas Bergh, Jonatan D. Lindh
Rok vydání: 2023
Předmět:
Zdroj: Breast Cancer Research and Treatment. 198:499-508
ISSN: 1573-7217
0167-6806
DOI: 10.1007/s10549-023-06887-2
Popis: Purpose Suboptimal adherence to adjuvant endocrine treatment (AET) is an important clinical concern. A correlation between CYP2D6 activity and tamoxifen discontinuation has been described. The main aim of this study was to investigate the consistency between pharmacy dispensation data and medical records on adherence to AET. Methods Adherence was calculated for patients with at least 4.5 years of follow up and was defined as Medical Possession Rate ≥ 80%. Subgroup analyses were performed based on menopausal status, recurrence risk and CYP2D6 activity. Results In 86% of the 1235 included patients the consistency between the two sources of information was within 80–125%. Poor consistency, Conclusions There was a good consistency between medical records and pharmacy dispensing data on the use of AET. Adherence to AET was adequate, especially when including switch to aromatase inhibitors. Surprisingly, CYP2D6 PMs had low adherence to tamoxifen, despite a likely reduced risk of side effects according to previous data.
Databáze: OpenAIRE
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