SERUM OMENTIN, VISFATIN, VASPIN ARE NOT USEFULL DIAGNOSTIC BIOMARKERS IN COLORECTAL CANCER
| Autor: | Şen, Fatma, Erdemli, Hacı Kemal, Bademler, Suleyman, Ilhan, Mehmet, Yavuzer, Hakan, Tambas, Makbule, Salıs, Osman, Kocabas, Ramazan, Bedir, Abdulkerim |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| DOI: | 10.18143/jisanh_v3i3_1268 |
| Popis: | Gastrointestinal carcinomas are more prevalent in obese populations compared to nonobese ones. Based on complex interplay between adipokines, obesity is also characterized by increased oxidative stress. Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to development of obesity-related complications. It was found both primary and metastatic carcinomas and may be critical in regulation of the oxidative status of cancer cells. This study investigated the omentin, visfatin and vaspin levels in patients with colorectal carcinomas (CRC).Total of 60 patients with CRC (male/female:25/35) and 30 controls (male/female:15/15) were enrolled. Results were given as median (%95 Cl). Mann-Whitney test was used for the comparison of groups.Serum omentin level was 32.2 (0.3-217.3) ng/L in CRC patients and 34.9 (11.3-123.4) ng/L in control group (P>0.05). Serum visfatin level was 6.8 (2.6-31.9) ng/mL in CRC patients and 9.2 (4.3-26.3) ng/L in controls (P>0.05). Serum vaspin level was 0.7 (0.4-7.6) ng/ml and 1.1 (0.6-4.2) ng/ml in CRC patients and control group, respectively (P>0.05). Serum omentin, visfatin and vaspin levels of CRC patients were not different than those of control group. Thus, serum omentin, visfatin and vaspin levels should not be used as a diagnostic biomarker of CRC. Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 3 (2016) |
| Databáze: | OpenAIRE |
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