ChemInform Abstract: Rhodium-Catalyzed 1,4-Addition of Arylboronic Acids to 3-Benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Derivatives

Autor:	Cécile Croix, Marie-Claude Viaud-Massuard, Gildas Prie, Charlotte Chaulet
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Chemistry Organic chemistry chemistry.chemical_element General Medicine Methylene Rhodium Catalysis
Zdroj:	ChemInform. 46
ISSN:	0931-7597
Popis:	7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-ones, as these substrates are exocyclic methylene lactamyl Michael acceptors. Ten new original derivatives of 1H-pyrrolo[2,3-b]pyridin-2(3H)-one have been obtained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6af9a70ecca109cfc114c8e868b5840 https://doi.org/10.1002/chin.201531208 Zobrazit plný text záznamu Plný text