New Insights into Human Immunodeficiency Virus—Type 1 Replication
| Autor: | Boyan Grigorov, R. Argirova, Jean-Luc Darlix, Delphine Muriaux |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Biotechnology & Biotechnological Equipment. 19:3-15 |
| ISSN: | 1314-3530 1310-2818 |
| DOI: | 10.1080/13102818.2005.10817147 |
| Popis: | Retroviruses comprise a large and widespread family of enveloped plus strand RNA viruses, which can infect most if not all vertebrates and cause diverse pathologies such as leukemia, sarcoma, neurodegeneration and immunodeficiency. The human immunodeficiency virus type 1 (HIV-1) is the causative agent of AIDS and a member of the Retroviridae family. Investigating the different steps of HIV-1 replication and the interactions of HIV-1 with components of the infected cell is of critical importance for the identification of novel therapeutic approaches and agents. In this review, we describe the early events of HIV-1 replication, namely how the virus recognizes and enters the target cell, the replication strategy and interactions between viral and cellular components and, the late stages corresponding to assembly and budding of progeny virions which necessitate viral proteins, RNA and cellular membranes. In addition, we report on the recent discoveries of cellular innate defense mechanisms against HIV-1. |
| Databáze: | OpenAIRE |
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