ChemInform Abstract: Synthesis, Single-Crystal Characterization and Preliminary Biological Evaluation of Novel Ferrocenyl Pyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives

Autor:	Hong-Shui Lv, Junying Miao, Dong-Soo Shin, Ji-Kun Li, Hua Su, Bai-Shan Wang, Jin-Ting Liu, Bao-Xiang Zhao, Yong-Sheng Xie, Hong-Ling Zhao
Rok vydání:	2010
Předmět:	Chemistry Stereochemistry Proton NMR General Medicine Carbon-13 NMR Single crystal Biological evaluation
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201019166
Popis:	A series of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6a57ba3b51d0b3044edb01d30b05cd1 https://doi.org/10.1002/chin.201019166 Zobrazit plný text záznamu Plný text