Sustained release from inert matrices I. Effect of macrocrystalline cellulose on aminophylline and theophylline release

Autor:	Sobhi Said, Hasan I. Al-Shora
Rok vydání:	1980
Předmět:	Inert Macrocrystalline Chromatography Pharmaceutical Science Microcrystalline cellulose chemistry.chemical_compound Microcrystalline Reaction rate constant chemistry medicine Theophylline Aminophylline Cellulose medicine.drug
Zdroj:	International Journal of Pharmaceutics. 6:11-18
ISSN:	0378-5173
DOI:	10.1016/0378-5173(80)90025-3
Popis:	The release of aminophylline and theophylline embedded in a matrix composed of different ratios of microcrystalline cellulose and glyceryl monostearate (or propylene glycol monostearate) was investigated. The result indicated that drug release within a certain period follows a diffusion-controlled matrix model, where the drug quantity released was proportional to the square root of time. The release rate was found to increase with increasing microcrystalline cellulose—glyceryl monostearate ratio. The logarithm of the rate constant was proportional to the fraction of microcrystalline cellulose in the matrix. The tablets prepared using solvent-evaporated matrix showed quicker release than those prepared from fused ones. Propylene glycol monostearate achieved similar, but somewhat quicker release, than glyceryl monostearate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6a3b4060c5e4ac4e76c11b08cc2b750 https://doi.org/10.1016/0378-5173(80)90025-3 Zobrazit plný text záznamu