Abstract B12: Recruitment of African American breast cancer pedigrees for The Jewels in Our Genes Study: Recruitment outcomes and sample characteristics

Autor: Veronica Meadows-Ray, Youjin Wang, Mattye Willis, Heather M. Ochs-Balcom, Detric Johnson, Lina Jandorf, Deborah O. Erwin
Rok vydání: 2014
Předmět:
Zdroj: Cancer Epidemiology, Biomarkers & Prevention. 23:B12-B12
ISSN: 1538-7755
1055-9965
DOI: 10.1158/1538-7755.disp13-b12
Popis: Background. Few studies have investigated the contribution of inherited genetic variation to breast cancer disparities and fewer have examined whether risk alleles shared in families may contribute to higher risk of aggressive tumors. One barrier is the challenge of effectively recruiting African American families for research. Methods. Using a community-based participatory research (CBPR) orientation, we utilized multi-level methods in an iterative fashion to recruit for a breast cancer genetic linkage study. We recruited affected relative pairs as well as discordant sibling pairs where possible. We analyzed our recruitment yield by method and calculated descriptive statistics for several demographic and clinical characteristics of families selected for genotyping, which includes 281 individuals from 106 pedigrees (197 affecteds, 84 unaffecteds). Results. We recruited 341 African American women (247 with breast cancer and 94 unaffecteds) from 127 families. The top three yields were obtained via collaboration with the Love Army of Women (34% of sample), The National Witness Project (NWP, 29% of sample), and previous epidemiologic studies (24% of sample). Within the set of 106 pedigrees selected for genotyping, 27 pedigrees have one affected relative, 68 pedigrees have 2 affecteds, 10 pedigrees have 3 affecteds, and one pedigree has 6 affecteds. Where adjudicated (n=141, 72%), the mean and median age at diagnosis was 51.6 years (SD 12.0) and 51.6 years, respectively. Affected women were younger at menarche (p=0.002) and more likely to be hysterectomized (p=0.018) compared to unaffected women. According to tumor receptor status, approximately 26% of cases are ER negative, 40% are PR negative, 49% are HER2 negative, and overall 16% are ER/PR/HER2 negative. Conclusions. Approaching recruitment of African American pedigrees with use of a multi-pronged approach that includes collaboration from the community can greatly facilitate success. While our sample has a slightly younger age of onset compared to African American cases in the general population (SEER median age for African Americans is 58 yrs), the sample approximates the US proportion of all invasive breast cancers in the US with regard to triple negative status (∼15%). Citation Format: Youjin Wang, Deborah O. Erwin, Lina Jandorf, Detric Johnson, Veronica Meadows-Ray, Mattye Willis, Heather Ochs-Balcom. Recruitment of African American breast cancer pedigrees for The Jewels in Our Genes Study: Recruitment outcomes and sample characteristics. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B12. doi:10.1158/1538-7755.DISP13-B12
Databáze: OpenAIRE
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