GENETIC VARIANTS OF ADIPONECTIN AND THERAPEUTIC EFFICIENCY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN PATIENTS TYPE 2 DIABETES MELLITUS
| Autor: | Maryana Gorshunska, Yuri Karachentsev, Nona Kravchun, E. Jansen, L. O. Atramentova, Olexander Gladkih, Nataliya Krasova, Zhanna Leshchenko, T. V. Tyzhnenko, Y. A. Opaleiko, A. K. Pochernyaev, V. V. Роltorak |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Problems of Endocrine Pathology. 43:5-14 |
| ISSN: | 2518-1432 2227-4782 |
| DOI: | 10.21856/j-pep.2013.1.01 |
| Popis: | In 61 type 2 diabetic patients it was defined single nucleotide polymorphism +276 G > T (rs1501299 ) in adiponectin gene and atherogenic potential dynamics (hormonal and metabolic parameters of insulin resistance, a pro-inflammatory state, oxidative status, adipokines) after daily administration for 12 weeks of omega-3 polyunsaturated fatty acids (Omacor) with the constant pattern of antidiabetic therapy. After the treatment, in all the surveyed it was revealed reduction of insulin resistance, while a significant increase in the levels of total adiponectin, total erythrocyte glutathione, as well as reduced levels of circulating insulin and osteoprotegerin were observed only in carriers of GG-genotype. These results suggest that genetic variations in the adiponectin gene can affect the therapeutic efficacy of omega-3 fatty acids, namely, to reduce the pattern of cardiovascular risk factors in type 2 diabetic patients in a Ukrainian population. |
| Databáze: | OpenAIRE |
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