| Popis: |
Changes in the concentration of two types of modified serum lipoproteins: peroxidated lipoproteins and Lp(a) with age, atherosclerosis and various risk factors for atherosclerosis were studied. Malondialdehyde level (an index of peroxidation) was significantly increased in the total serum and in the LDL fraction of atherosclerotic and of diabetic patients. The mean concentration of Lp(a) was significantly increased in patients with coronary heart disease or cerebrovascular disease; the elevation was more expressed when atherosclerosis was associated with type II hyperlipidemia or diabetes. In 40–60% of children with familial risk for atherosclerosis increased Lp(a) concentrations were measured as well. The mechanism of the pathogenicity of modified lipoproteins was successfully studied in cell culture experiments and by in vitro investigations. In the course of prevention/regression studies, plasma factors, interfering with the binding of LDL to arterial extracellular matrix were isolated; their physiological role has been investigated in model experiments. |
