Inflammatory Markers and Disability in Chinese Older Adults
| Autor: | Bowen Sun, Birong Dong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Screening test business.industry Inflammation Omics 03 medical and health sciences 0302 clinical medicine Physical performance Internal medicine medicine Physical therapy Elderly people In patient 030212 general & internal medicine medicine.symptom Severe disability business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Gerontology & Geriatric Research. |
| ISSN: | 2167-7182 |
| Popis: | Background: There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and disability and physical performance in older persons. Methods: We conducted analyses of 70 adults aged 61 and older, examined serum levels of IL-6, IL-10, TNF-α , MIP-1α , MIP-1β , MCP-1 , and MCP-3 from 59 patients with disability and 11 normal controls. We further categorized the 59 patients with disability into either mild (n=34), moderate (n=15) or severe disability (n=10) using the Disability Level Assessment of the Elderly. The levels of the inflammatory markers were compared amongst these groups as well as with the control. We also evaluated the relationship of several inflammatory markers and physical performance in elderly people with disability. The levels of inflammatory markers were measured by the Luminex Technology. Results: The levels of IL-6 , IL-10 , TNF-α , MIP-1α , MIP-1β , and MCP-3 in patients with disability were significantly higher than those in the control group; higher levels of the IL-6 and MCP-3 were associated with disability(P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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