Vascular variability anomalies (VVAs) in children
| Autor: | Franz Halberg, M. D. Mitish, Othild Schwartzkopff, Lyazzat Gumarova, L. Namazova-Baranova, Ivan Jevgenievitch Smirnov, Anatoly Masalov, Elena V. Syutkina, Olga Viktorovna Kozhevnikova, Germaine Cornelissen |
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| Rok vydání: | 2014 |
| Předmět: |
Pediatrics
medicine.medical_specialty General Immunology and Microbiology Test group business.industry General Neuroscience Health Toxicology and Mutagenesis Cosinor analysis Biomedical Engineering Diastole General Medicine Data series General Biochemistry Genetics and Molecular Biology Pulse pressure Cardiovascular monitoring Increased risk Artificial Intelligence Medicine Circadian rhythm General Pharmacology Toxicology and Pharmaceutics General Agricultural and Biological Sciences business |
| Zdroj: | Journal of Applied Biomedicine. 12:147-153 |
| ISSN: | 1214-0287 1214-021X |
| DOI: | 10.1016/j.jab.2014.02.004 |
| Popis: | This work aims at studying in children the prevalence of some vascular variability anomalies (VVAs), i.e. indices of an increased risk of heart and vessel diseases revealed by chronobiologic analysis of cardiovascular monitoring data – systolic (SBP) and diastolic (DBP) MESOR-hypertension/hypotension, circadian hyper-amplitude-tension (CHAT), ecphasia and an excessive pulse pressure (EPP). A reference group of 138 healthy Moscow schoolchildren (age 12–17 years) was used for determination of 90% prediction limits for the circadian parameters of SBP and DBP, specified by gender and age (or height). The test group included another 194 children of the same age range with headache and abnormal BP values by casual measurement. BP data series from each child were analyzed by the COSINOR method. VVAs were found in 44.8% of children from the test group. In boys, VVAs occur more often than in girls (51.5% vs. 30.6%). One child may have up to 3 VVAs. The presence of VVAs may be related to an elevated BMI. The most common VVAs in childhood are the abnormalities of PP and systolic CHAT. Cosinor analysis can reveal a large number of children with PP higher than a threshold (60 mmHg) during a relatively long portion of the day (more than 1/3 of the 24 h span). |
| Databáze: | OpenAIRE |
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