P0072 Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer

Autor:	Jialiang Li, Jianying Zeng, Fei Yao, Lizhi Niu, Kecheng Xu, Meng-Tian Liao, Li Li, Jiansheng Zuo, Feng Mu, Chun-Yan Liu, Jibing Chen
Rok vydání:	2014
Předmět:	Oncology Cancer Research medicine.medical_specialty Hepatocellular cancer business.industry medicine.medical_treatment Cryoablation Cryotherapy Immunotherapy Cryosurgery Combined treatment Internal medicine medicine Overall survival business
Zdroj:	European Journal of Cancer. 50:e29
ISSN:	0959-8049
DOI:	10.1016/j.ejca.2014.03.116
Popis:	Background We aimed to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrahepatic and extrahepatic tumours) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer. Methods We divided 45 patients into cryoimmunotherapy ( n = 21), cryotherapy ( n = 12), immunotherapy ( n = 5) and untreated ( n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up. Findings Median OS was higher following cryoimmunotherapy (32 months) or cryotherapy (17.5 months; p p p Interpretation Cryotherapy and, especially, cryoimmunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryoimmunotherapy treatments was associated with a better prognosis than single cryoimmunotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d68232deb31e75b654d2c1ddc2b528e1 https://doi.org/10.1016/j.ejca.2014.03.116 Zobrazit plný text záznamu Full Text from ScienceDirect