PHARMACOKINETICS AND CLINICAL SAFETY OF A SUSTAINED-RELEASE FORMULATION OF CEFTIOFUR CRYSTALLINE FREE ACID IN RINGNECK DOVES (STREPTOPELIA RISORIA) AFTER A SINGLE INTRAMUSCULAR INJECTION
| Autor: | Lisa A. Tell, Paul P. Calle, S. E. Wetzlich, Alisa L. Newton, Marc T. Valitutto, Bonnie L. Raphael, Jennifer C. Kishbaugh |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.medical_specialty General Veterinary Clinical pathology biology 040301 veterinary sciences medicine.drug_class business.industry Streptopelia Cephalosporin Antibiotics Half-life Physiology 04 agricultural and veterinary sciences General Medicine biology.organism_classification 030308 mycology & parasitology 0403 veterinary science 03 medical and health sciences Minimum inhibitory concentration Pharmacokinetics medicine Animal Science and Zoology Intramuscular injection business |
| Zdroj: | Journal of Zoo and Wildlife Medicine. 52 |
| ISSN: | 1042-7260 |
| DOI: | 10.1638/2019-0122 |
| Popis: | Ceftiofur crystalline free acid (CCFA) is a third-generation, oil-based, cephalosporin antimicrobial marketed as a once weekly treatment in cattle and swine, and as a two-time dose with 10-day duration in horses. Because handling and restraint times can be reduced, long-acting antibiotic preparations are particularly useful for treatment of nondomestic species. This study evaluated the pharmacokinetics of CCFA in ringneck doves (Streptopelia risoria). A single intramuscular (IM) injection of CCFA at 50 mg/kg was administered to each of 30 doves, and blood was collected from subsamples of 6 birds at predetermined sampling times (i.e., with a postinjection range of 0.5 to 192 hr). All ringneck doves were scheduled for euthanasia because of reasons unrelated to the study; this was performed at the conclusion of the study; and complete postmortem and histopathologic examinations were performed. Plasma concentrations of CCFA remained above the minimum inhibitory concentration (1.0 µg/ml; observed for most avian pathogenic bacteria) for 108 hr. No abnormalities were identified on individual birds before and after clinical pathology results (i.e., hematocrits and plasma biochemistry profiles), and only minimal gross and histopathologic changes such as mild tissue inflammation at the injection site were observed. Based on these results, one IM injection of CCFA at 50 mg/kg seems to be a potential option for treatment of ringneck doves. |
| Databáze: | OpenAIRE |
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