Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice
| Autor: | V. V. Kanygin, A.I. Kasatova, E.L. Zavyalov, R. A. Mukhamadiyarov, A. I. Kichigin, Alphiya R. Tsygankova, T. Ya. Gusel’nikova |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
Biodistribution 010405 organic chemistry Radiochemistry Glioblastoma cell line chemistry.chemical_element General Chemistry Scid mice 010402 general chemistry 01 natural sciences nervous system diseases 0104 chemical sciences Neutron capture chemistry Inductively coupled plasma atomic emission spectroscopy Boron |
| Zdroj: | Russian Chemical Bulletin. 69:601-607 |
| ISSN: | 1573-9171 1066-5285 |
| Popis: | The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated. |
| Databáze: | OpenAIRE |
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