Cutting Edge: B Cells Are Essential for Protective Immunity against Salmonella Independent of Antibody Secretion

Autor:	Mark J. Shlomchik, Sing Sing Way, Stephen J. McSorley, Minelva R. Nanton
Rok vydání:	2012
Předmět:	Protective immunity Salmonella Secondary infection Immunology Virulence Salmonella infection Biology Acquired immune system medicine.disease medicine.disease_cause Typhoid fever Microbiology Bacteremia medicine Immunology and Allergy
Zdroj:	The Journal of Immunology. 189:5503-5507
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.1201413
Popis:	Typhoid fever and nontyphoidal bacteremia caused by Salmonella remain critical human health problems. B cells are required for protective immunity to Salmonella, but the mechanism of protection remains unclear. In this study, we immunized wild-type, B cell–deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella and examined protection against secondary infection. As expected, wild-type mice were protected and B cell–deficient mice succumbed to secondary infection. Interestingly, mice with B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmonella infection. The susceptibility of B cell–deficient mice correlated with marked reductions in CD4 T cell IFN-γ production after secondary infection. Taken together, these data suggest that the primary role of B cells in acquired immunity to Salmonella is via the development of protective T cell immunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d67b904c1c20dbc2fb7d1e80a7a68a27 https://doi.org/10.4049/jimmunol.1201413 Zobrazit plný text záznamu