Maternal BMI Changes from the Prepregnancy to Postpartum Period are Associated with Postpartum Cardiometabolic Risk Factors: A Longitudinal Study

Autor: Huafan Zhang, Jianmin Niu, Linlin Wu, Xiaoxia Wu, Yixuan Chen, Fu-Ying Tian, Aiqi Yin, Fengqiao Hu, Jianing Tong, Xuna Huang, Yanmei Wan Wan
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2546340/v1
Popis: Purpose To investigate the associations between the total body mass index(BMI) change at 3 or 4 years postpartum compared to the prepregnancy and cardiometabolic risk factors. Methods This longitudinal study included 1305 participants. Based on the total postpartum BMI changes, they were divided into 1.7 units groups using the interquartile range. Multiple linear regression models were used to analyze the associations. Results Compared to the reference group, there was a progressive increase in the βcoefficient (βcoef) of homeostasis model assessment of insulin resistance (HOMA-IR) of cardiometabolic risk in the following groups: the ‘0-1.7 units’ group with the ‘high prepregnancy BMI + high gestational weight gain (GWG) trajectory’ [βcoef 0.33; 95% confidence intervals (CI): 0.22, 0.44)] or the ‘very high prepregnancy BMI + very high GWG trajectory’ [0.66; (0.45, 0.88)] and the ‘>1.7 units’ group with the ‘normal prepregnancy BMI + normal GWG trajectory’ [0.33; (0.22, 0.44)], the ‘high prepregnancy BMI + high GWG trajectory’ [0.54; (0.41, 0.67)] or the ‘very high prepregnancy BMI + very high GWG trajectory’ [0.97; (0.79, 1.15)]. However, the ‘ 1.7 units are positively associated with cardiometabolic risk factors, especially those with a high prepregnancy BMI and high GWG. Conversely, women with a postpartum weight loss > 0 units have negative association with cardiometabolic risk factors.
Databáze: OpenAIRE