Applying Biopharmaceutical Classification System criteria to predict the potential effect of Cremophor® RH 40 on fexofenadine bioavailability at higher doses
| Autor: | Soha M. El-Masry, Heba M. El-Bedaiwy, Sally A. Helmy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fexofenadine
Chemistry Potential effect Pharmaceutical Science 02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Bioavailability 03 medical and health sciences 0302 clinical medicine Biopharmaceutical Pharmacokinetics medicine Cremophor RH 40 0210 nano-technology medicine.drug |
| Zdroj: | Therapeutic Delivery. 11:447-464 |
| ISSN: | 2041-6008 2041-5990 |
| Popis: | Aim: To study the impact of various permeability enhancers on fexofenadine bioavailability. Furthermore, to predict the potential effect of Cremophor® RH 40 on fexofenadine pharmacokinetics at higher doses using Biopharmaceutical Classification System criteria. Experimental methods: The effect of the dose increase (60–360 mg) on the dissolution and permeability behavior of fexofenadine-Cremophor RH 40 formulations was studied in humans. The Biopharmaceutical Classification System criteria of the drug was determined. Results & conclusion: Cremophor RH 40 improved the dissolution and bioavailability of fexofenadine. The pharmacokinetics increased linearly with the dose increase. Absorption number (An) was significantly increased after addition of Cremophor RH 40 in comparison to an unprocessed drug. Similar An values were observed throughout the same dose range. The dose number (D0) values were n) values were >1 at the same dose level. |
| Databáze: | OpenAIRE |
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