Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication
| Autor: | Kazuo Takei, Takaya Aoki, Takao Itoi, Yuu Takagi, Norihisa Noguchi, Mikinori Kataoka, Fuminori Moriyasu, Satoru Taira, Masanori Sasatsu, Hiromi Serizawa, Takashi Kawai, Kouhei Kawakami, Emiko Rimbara |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Stomach macromolecular substances Helicobacter pylori biology.organism_classification medicine.disease Gastroenterology digestive system diseases Endoscopy medicine.anatomical_structure Atrophy Pepsin Internal medicine medicine Gastric mucosa biology.protein Pharmacology (medical) Helicobacter General Pharmacology Toxicology and Pharmaceutics business Antrum |
| Zdroj: | Alimentary Pharmacology Therapeutics Symposium Series. 2:23-30 |
| ISSN: | 1746-6342 1746-6334 |
| DOI: | 10.1111/j.1746-6342.2006.00022.x |
| Popis: | Summary Background Levels of pepsinogen have been reported to correlate with the degree of gastric atrophy in Helicobacter pylori-infected gastric mucosa. Aim To investigate the relationship between PG levels and histological atrophy before and after H. pylori eradication. Methods Eradication therapy was conducted on 180 H. pylori-positive patients with upper gastrointestinal conditions. Endoscopy was performed prior to and at 2, 12 and 24 months after successful eradication therapy. Histological findings were scored using the updated Sydney System in the antrum and the corpus of the stomach. Pepsinogen was measured. Results Pepsinogen I levels dropped significantly at 2 months after the eradication. By 12 months and 24 months post-eradication they had risen again. Histological improvement was seen in atrophy at all sites at 24 months after the eradication. A significant correlation between atrophy and pepsinogen I was seen from prior to eradication. The correlation coefficient was greater at 2 months post-eradication, decreased again at 12 months and was no longer significant at 24 months. Conclusions Our results suggest that pepsinogen levels correlate with the degree of gastric mucosal atrophy prior to and soon after successful eradication therapy, but that the degree of correlation subsequently declines over time. |
| Databáze: | OpenAIRE |
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