Role ofATG10 expression quantitative trait loci in non-small cell lung cancer survival
| Autor: | Zhibin Hu, Yayun Gu, Meng Zhu, Cheng Wang, Hongxia Ma, Juncheng Dai, Li Qin, Guangfu Jin, Caiwang Yan, Kaipeng Xie, Xiaoan Liu, Hui Wang, Hongbing Shen, Fangzhi Du, Cheng Liang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Genetics Cancer Research medicine.medical_specialty Single-nucleotide polymorphism Methylation Quantitative trait locus Biology medicine.disease 03 medical and health sciences 030104 developmental biology Internal medicine Cancer genome Expression quantitative trait loci medicine Non small cell Lung cancer Gene |
| Zdroj: | International Journal of Cancer. 139:1564-1573 |
| ISSN: | 0020-7136 |
| DOI: | 10.1002/ijc.30205 |
| Popis: | The aim of this article was to evaluate whether genetic variants in autophagy-related genes affect the overall survival (OS) of non-small cell lung cancer (NSCLC) patients. We analyzed 14 single nucleotide polymorphisms (SNPs) in core autophagy-related genes for OS in 1,001 NSCLC patients. Three promising SNPs in ATG10 were subsequently annotated by the expression quantitative trait loci (eQTL) and methylation quantitative trait loci (meQTL) analyses based on Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. We observed that the variants of rs10514231, rs1864182 and rs1864183 were associated with poor lung cancer survival (HR = 1.33, 95% CI = 1.07-1.65; HR = 1.43, 95% CI = 1.13-1.81; HR = 1.38, 95% CI = 1.14-1.68, respectively) and positively correlated with ATG10 expression (all p |
| Databáze: | OpenAIRE |
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