Absence of Airway Secretion Accumulation Predicts Tolerance of Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis
| Autor: | Vincent Cadiergue, Pierre Le Cam, Nadia Vandenberghe, Jean-Philippe Camdessanché, Anne-Evelyne Vallet, Pascal Beuret, Stéphane Peysson, Claude Guérin, Françoise Bouhour, Christophe Vial, Sylvie Bin-Dorel, Jean-Christophe Antoine, Isabelle Court-Fortune, Emmanuel Broussolle, François Philit, Thierry Petitjean, Frédéric Dailler, Sylvie Jay |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Multivariate analysis business.industry General Medicine Odds ratio Critical Care and Intensive Care Medicine medicine.disease Surgery Quality of life Anesthesia medicine Clinical endpoint Amyotrophic lateral sclerosis Prospective cohort study Airway business Cohort study |
| Zdroj: | Respiratory Care. 58:1424-1432 |
| ISSN: | 1943-3654 0020-1324 |
| Popis: | OBJECTIVE: To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS: We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The primary end point was NIV tolerance at 1 month. Subjects, several of whom failed to complete the study, were classified as “tolerant” or “poorly tolerant,” according to the number of hours of NIV use (more or less than 4 h per night, respectively). RESULTS: Eighty-one subjects, 73 of whom also attended the 1-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilization predicted tolerance at 1 month (77.6% and 75.3% of subjects, respectively). Multivariate analysis disclosed 3 factors predicting good NIV tolerance: absence of airway secretions accumulation prior to NIV onset (odds ratio 11.5); normal bulbar function at initiation of NIV (odds ratio 8.5); and older age (weakly significant, odds ratio 1.1). CONCLUSION: Our study reveals 3 factors that are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance. |
| Databáze: | OpenAIRE |
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