Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies
| Autor: | Silvio D. Brugger, Matthias Paprotny, Reto Schüpbach, Omar Ali, Christian R Kahlert, Alexandra Popa, Lukas Flatz, Philipp Kohler, Sarah Thiel, Myriam Weber, Lukas Kern, Philipp K Bühler, Lorenz Risch, Josef M. Penninger, Werner C. Albrich, Pietro Vernazza, Alejandro Gómez-Mejia, David Bomze, Andreas Bergthaler |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Immunoglobulin A Coronavirus disease 2019 (COVID-19) biology business.industry Retrospective cohort study medicine.disease medicine.disease_cause Autoimmunity Elevated serum Infectious Diseases immune system diseases Antiphospholipid syndrome Cohort Immunology biology.protein Medicine Antibody business |
| Zdroj: | Clinical Infectious Diseases. 73:1746-1746 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciab532 |
| Popis: | BACKGROUND: Severe coronavirus disease 2019 (COVID-19) frequently entails complications that bear similarities to autoimmune diseases. To date, there are little data on possible immunoglobulin (Ig) A-mediated autoimmune responses. Here, we aim to determine whether COVID-19 is associated with a vigorous total IgA response and whether IgA antibodies are associated with complications of severe illness. Since thrombotic events are frequent in severe COVID-19 and resemble hypercoagulation of antiphospholipid syndrome, our approach focused on antiphospholipid antibodies (aPL). METHODS: In this retrospective cohort study, clinical data and aPL from 64 patients with COVID-19 were compared from 3 independent tertiary hospitals (1 in Liechtenstein, 2 in Switzerland). Samples were collected from 9 April to 1 May 2020. RESULTS: Clinical records of 64 patients with COVID-19 were reviewed and divided into a cohort with mild illness (mCOVID; 41%), a discovery cohort with severe illness (sdCOVID; 22%) and a confirmation cohort with severe illness (scCOVID; 38%). Total IgA, IgG, and aPL were measured with clinical diagnostic kits. Severe illness was significantly associated with increased total IgA (sdCOVID, P = .01; scCOVID, P < .001), but not total IgG. Among aPL, both cohorts with severe illness significantly correlated with elevated anticardiolipin IgA (sdCOVID and scCOVID, P < .001), anticardiolipin IgM (sdCOVID, P = .003; scCOVID, P< .001), and anti-beta 2 glycoprotein-1 IgA (sdCOVID and scCOVID, P< .001). Systemic lupus erythematosus was excluded from all patients as a potential confounder. CONCLUSIONS: Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity. |
| Databáze: | OpenAIRE |
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