Nasal shedding of Mycobacterium tuberculosis in wild boar is related to generalised tuberculosis and concomitant infections
| Autor: | Pedro Fernández Llario, Remigio Martínez, Pilar Gonçalves, Javier Hermoso de Mendoza, Alfredo Garcia, David Risco, Alberto Quesada, Waldo L. García-Jiménez, Oscar Barquero-Perez, Rosario Cerrato, María Bravo |
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| Rok vydání: | 2019 |
| Předmět: |
Tuberculosis
General Veterinary biology 040301 veterinary sciences 0402 animal and dairy science Generalised tuberculosis 04 agricultural and veterinary sciences General Medicine Disease biology.organism_classification medicine.disease 040201 dairy & animal science Virology 0403 veterinary science Mycobacterium tuberculosis Porcine circovirus Wild boar biology.animal Concomitant Bovine tuberculosis medicine |
| Zdroj: | Veterinary Record. 185:629-629 |
| ISSN: | 0042-4900 |
| Popis: | Background Wild boar is an important reservoir of Mycobacterium tuberculosis variant bovis, the main causative agent of bovine tuberculosis (bTB). A proportion of tuberculosis (TB)-affected wild boars shed M tuberculosis by nasal route, favouring the maintenance of bTB in a multihost scenario. The aim of this work was to assess if M tuberculosis nasal excretion is influenced by factors commonly associated with high TB prevalence in wild boar. Methods TB diagnosis and M tuberculosis isolation were carried out in 112 hunted wild boars from mid-western Spain. The association between the presence of M tuberculosis DNA in nasal secretions and explanatory factors was explored using partial least squares regression (PLSR) approaches. Results DNA from M tuberculosis was detected in 40.8 per cent nasal secretions of the TB-affected animals. Explanatory factors provided a first significant PLSR X’s component, explaining 25.70 per cent of the variability observed in M tuberculosis nasal shedding. The presence of M tuberculosis in nasal secretions is more probable in animals suffering from generalised TB and mainly coinfected with Metastrongylus species and porcine circovirus type 2, explaining nearly 90 per cent of the total variance of this model. Conclusion Measures aiming to control these factors could be useful to reduce M tuberculosis shedding in wild boar. |
| Databáze: | OpenAIRE |
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