Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation

Autor:	Morteza Moradi, Pardis Kalantarian, Mohammad Taher Hojjati, Yadollah Yamini, Ismaeil Harrian, Ali Esrafily, Alireza Vatanara
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Supercritical carbon dioxide Chemistry General Chemical Engineering Vaporization Analytical chemistry Finasteride Solvation Organic chemistry General Chemistry Dutasteride Flutamide
Zdroj:	Journal of Chemical & Engineering Data. 55:1056-1059
ISSN:	1520-5134 0021-9568
DOI:	10.1021/je900520a
Popis:	The solubilities of flutamide, dutasteride, and finasteride in supercritical carbon dioxide were investigated at temperatures of (308.0, 318.0, 328.0, 338.0, and 348.0) K and various pressures in the range of (12.1 to 35.5) MPa. The measured results were then correlated using semiempirical equations presented by Chrastil and Bartle. With optimally fitted parameters, the average absolute relative deviations (AARD) ranged from 0.122 to 0.260 and from 0.024 to 0.137 for Chrastil and Bartle models, respectively. The heat of drug−CO2 solvation and that of drug vaporization were approximated in the range of (−17.4 to −16.8) kJ·mol−1 and (73.7 to 90.1) kJ·mol−1, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d655fa17b198e69c284eb7879844bc8a https://doi.org/10.1021/je900520a Zobrazit plný text záznamu