Sumo Modification of Ion Channels
| Autor: | Mark L. Benson, Jorge A. Iñiguez-Lluhí, Jeffrey R. Martens |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Voltage-gated ion channel Chemistry Inward-rectifier potassium ion channel SUMO protein Cellular homeostasis Voltage-gated potassium channel Light-gated ion channel Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Ligand-gated ion channel 030217 neurology & neurosurgery Ion channel |
| Zdroj: | SUMO Regulation of Cellular Processes ISBN: 9783319500430 |
| DOI: | 10.1007/978-3-319-50044-7_8 |
| Popis: | Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is comparatively small, ion channels represent one important new class of these proteins. Ion channels are responsible for the control of membrane excitability and therefore are critical for fundamental physiological processes such as muscle contraction, neuronal firing, and cellular homeostasis. As such, these ion-conducting proteins are subject to precise regulation. Recently, several studies have identified sumoylation as a novel mechanism of modulating ion channel function. These studies expand the list of known functions of sumoylation and reveal that, in addition to its more established role in the regulation of nuclear proteins, this modification plays important roles at the cytoplasmic face of membranes. |
| Databáze: | OpenAIRE |
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