Autoantibodies to nucleolin in systemic lupus erythematosus and other diseases

Autor:	S Minota, W N Jarjour, N Suzuki, Y Nojima, R A Roubey, T Mimura, A Yamada, T Hosoya, F Takaku, J B Winfield
Rok vydání:	1991
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 146:2249-2252
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.146.7.2249
Popis:	The 110-kDa intracellular phosphoprotein (110K) described previously by this laboratory as a common IgM autoantigen in SLE and certain other systemic autoimmune disorders and viral infections is identified as nucleolin in the present investigation. Using rabbit antiserum to rat nucleolin as a probe, IgM autoantibody-reactive 110K co-migrated with human lymphocyte nucleolin in one- and two-dimensional immunoblots. Rabbit anti-nucleolin also specifically depleted autoreactive 110K from detergent lysates of human cells. Because nucleolin shares amino acid sequence similarity and/or forms dynamic particles with other prominent autoantigens, the present observation raises the possibility that the nucleolin/anti-nucleolin system may be of special significance for the development of humoral autoreactivity to nuclear Ag.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d650ee924a6e1c90eea66bef824f49ad https://doi.org/10.4049/jimmunol.146.7.2249 Zobrazit plný text záznamu