Synthetic studies on neomarinone: practical and efficient stereoselective synthesis of the side chain

Autor:	Luis A. Sarandeses, José Pérez Sestelo, Rosa M. Suárez, M. Montserrat Martínez
Rok vydání:	2007
Předmět:	Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Side chain Organic chemistry Stereoselectivity Alkylation Neomarinone Biochemistry
Zdroj:	Tetrahedron Letters. 48:6493-6495
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2007.07.064
Popis:	A practical and efficient stereoselective synthesis of the side chain of neomarinone is reported. The synthesis was achieved in six steps (41% overall yield) from 2-methyl-2-cyclohexenone. The key step is a novel stereoselective 1,4-conjugate addition/enolate alkylation by an epoxide-opening reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d6498e2aec1cfeaa2c871e234638850b https://doi.org/10.1016/j.tetlet.2007.07.064 Zobrazit plný text záznamu Full Text from ScienceDirect