Pulmonary adenocarcinoma with mucin production modulates phenotype according to common genetic traits: a reappraisal of mucinous adenocarcinoma and colloid adenocarcinoma
| Autor: | Ugo Pastorino, Alessandra Fabbri, Angelica Sonzogni, Federica Perrone, Mara Cossa, Giuseppe Pelosi, Elena Tamborini, Fabrizio Bianchi, Adele Busico, Barbara Valeri, Alberto Cavazza, Benedetta Picciani, Giulio Rossi, Iolanda Capone |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty biology Mucin Chromogranin A Vimentin respiratory system medicine.disease medicine.disease_cause digestive system diseases Pathology and Forensic Medicine Alveolar cells 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Keratin 7 medicine biology.protein Adenocarcinoma KRAS MUC1 |
| Zdroj: | The Journal of Pathology: Clinical Research. 3:139-151 |
| ISSN: | 2056-4538 |
| DOI: | 10.1002/cjp2.67 |
| Popis: | Whether invasive mucinous adenocarcinoma (IMA) and colloid adenocarcinoma (ICA) of the lung represent separate tumour entities, or simply lie within a spectrum of phenotypic variability, is worth investigating. Fifteen ICA, 12 IMA, 9 ALK-rearranged adenocarcinomas (ALKA), 8 non-mucinous KRAS-mutated adenocarcinomas (KRASA) and 9 mucinous breast adenocarcinomas (MBA) were assessed by immunohistochemistry for alveolar (TTF1, cytoplasmic MUC1), intestinal (CDX-2, MUC2), gastric (membrane MUC1, MUC6), bronchial (MUC5AC), mesenchymal (vimentin), neuroendocrine (chromogranin A, synaptophysin), sex steroid hormone-related (oestrogen and progesterone receptors), pan-mucinous (HNF4A) and pan-epithelial (keratin 7) lineage biomarkers and by targeted next generation sequencing (TNGS) for 50 recurrently altered cancer genes. Unsupervised clustering analysis using molecular features identified cluster 1 (IMA and ICA), cluster 2 (ALKA and KRASA) and cluster 3 (MBA) (p |
| Databáze: | OpenAIRE |
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