Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives

Autor:	S. R. Maturi, Ch. P. Koteswara Rao, G. Kali Charan, B. Srinu, T. B. Rao
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Cell culture Pyridine MTT assay General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Human cancer 0104 chemical sciences
Zdroj:	Russian Journal of General Chemistry. 89:1023-1028
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363219050244
Popis:	In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl] phenyl}thiazolo[4,5-b]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g, and 11j exhibit activity higher than the standard drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d63d2c23d1094a43f697848a369cc4dc https://doi.org/10.1134/s1070363219050244 Zobrazit plný text záznamu Plný text ve formátu PDF