Protective effects of COVID-19 vaccination on endothelial function of patients with COVID-19
| Autor: | S Lampsas, E Oikonomou, N Souvaliotis, G A Papamikroulis, T Lytra, S Sarantos, V C Mystakidi, P Pantelidis, K Kalogeras, P Theofilis, A Tsatsaragkou, G Siasos, C Tsioufis, D Tousoulis, M Vavuranakis |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Background Endotheliilitis COVID-19 related endothelial dysfunction plays a key role in the cardiovascular complications of the disease. Vaccine against SARS-CoV-2 protects against severe COVID-19 and from adverse effects. We evaluated the impact of vaccination on COVID-19 induced endothelial dysfunction. Methods We enrolled 45 patients hospitalized for COVID-19 (either vaccinated or not against SARS-CoV-2). Clinical information and laboratory findings were collected, and brachial artery flow-mediated dilation (FMD) was evaluated as a measure of endothelial function. Subjects without COVID-19 were used as the control group. All patients were hospitalized in a medical ward classified according to the World Health Organization (WHO) scale. Results There was no difference in age (62±10 years vs. 65±8 years, p=0.12) and male sex prevalence (56% vs. 49%, p=0.53) between patients with COVID-19 and control subjects. Of the patients with COVID-19, 44% (20) were vaccinated against SARS-CoV-2. FMD was impaired in patients with COVID-19 compared to controls (4.35±3.56% vs. 7.36±2.91%, p Conclusion Hospitalized patients with COVID-19 present endothelial dysfunction in the acute phase of the disease. Endothelial function in unvaccinated patients with COVID-19 is impaired compared to control subjects as well as compared to vaccinated patients with COVID-19. This data provides insights on the protective role of vaccination against COVID-19 related endotheliitis. Funding Acknowledgement Type of funding sources: None. |
| Databáze: | OpenAIRE |
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