Subchronic Vapor Inhalation Toxicity Studies on 3.1 Oil in Male Fischer 344 Rats

Autor:	David R. Mattie, Carlyle D. Flemming, H. F. Leahy, H. G. Wall, E.R. Kinkead, R. E. Whitmire, E. C. Kimmel
Rok vydání:	1991
Předmět:	Kidney Chlorofluorocarbon Inhalation Chemistry Health Toxicology and Mutagenesis Toxicology chemistry.chemical_compound Animal science medicine.anatomical_structure Toxicity medicine Alkaline phosphatase Blood urea nitrogen Oil toxicity Hyaline
Zdroj:	Inhalation Toxicology. 3:357-377
ISSN:	1091-7691 0895-8378
DOI:	10.3109/08958379109145295
Popis:	3.1 Oil is a chlorofluorocarbon oil consisting of C6 and C8 oligomers of chlorotriflu-oroethylene. Physical properties such as high thermal stability, good lubricity, and high dielectric strength make 3.1 oil promising for potential use in hydraulic fluid systems. A previous inhalation study indicated that the liver is the target organ of 3.1 oil toxicity. Cross liver hypertrophy and microscopic hepatocytomegaly were the prime lesions noted. To determine a no-effect concentration, male Fischer 344 rats were exposed to air only, or vapor concentrations of 10, 50, or 250 mg 3.1 oil/m3 for 13 wk. Mean body weights of the highest concentration test group were slightly, but not significantly, depressed during the final two-thirds of the study. Alkaline phosphatase and blood urea nitrogen values were increased in this group at sacrifice. Significant concentration-related increases in relative kidney and liver weights occurred in the 250 and 50 mg 3.1 oil/m3 groups. Hyaline droplet distribution and sever...
Databáze:	OpenAIRE
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