Immunomodulatory drugs can inhibit the extracellular release of HMGB1 from cultured human monocytes
| Autor: | Hanna Schierbeck, Therese Östberg, Ulf Andersson, Heidi Wähämaa, H. Erlandsson Harris |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
biology
business.industry Immunology Arthritis chemical and pharmacologic phenomena Inflammation Endogenous mediator Pharmacology medicine.disease HMGB1 General Biochemistry Genetics and Molecular Biology Rheumatology Synovitis Rheumatoid arthritis medicine biology.protein Extracellular Immunology and Allergy medicine.symptom Nuclear protein business |
| Zdroj: | Annals of the Rheumatic Diseases. 69:A36-A37 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2010.129627c |
| Popis: | The endogenous, nuclear protein High Mobility Group Box chromosomal protein 1(HMGB1) is secreted by activated macrophages/monocytes and, once extracellular, promotes inflammation. Extracellular HMGB1 is present in the synovitis of patients with rheumatoid arthritis (RA) and blockade of HMGB1 by specific antibodies ameliorates experimental arthritis. In addition, intra-articular injections of recombinant HMGB1 induce arthritis in mice. The authors hypothesise that HMGB1 represents an endogenous mediator of arthritis as well as a target molecule for successful therapeutic … |
| Databáze: | OpenAIRE |
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