The synchronization of chemotherapy to circadian rhythms and irradiation in pre-operative chemoradiation therapy with hyperthermia for local advanced rectal cancer. Abbreviations: 5-FU 5-fluorouracil LV Leucovorin APR abdomino-perineal resection
| Autor: | Tetsuo Nonaka, Mariko Shioya, Soichi Tsutsumi, Hideyuki Sakurai, Takashi Nakano, Satoru Yamaguchi, K. Harashima, Takayuki Asao, Hiroyuki Kuwano |
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| Rok vydání: | 2006 |
| Předmět: |
Hyperthermia
Cancer Research Chemotherapy medicine.medical_specialty Physiology Colorectal cancer business.industry medicine.medical_treatment Rectum medicine.disease Surgery Radiation therapy medicine.anatomical_structure Physiology (medical) Intensive care medicine Rectal Adenocarcinoma business Adverse effect |
| Zdroj: | International Journal of Hyperthermia. 22:399-406 |
| ISSN: | 1464-5157 0265-6736 |
| Popis: | Purpose: The therapeutic and adverse effects of pre-operative chrono-chemoradiation with local hyperthermia for patients with rectal adenocarcinoma were evaluated.Materials and methods: Pre-operative radiation therapy of a total dose of 40 Gy (n = 10) or 50 Gy (n = 19) on the whole pelvis and hyperthermia once a week during the radiation therapy for 1 h were performed for patients with T2–T4 rectal adenocarcinoma. Chemotherapy consisted of 5-FU (250 mg m−2 per day) and LV (25 mg m−2 per day) administered by continuous infusion in the night for 5 days a week in the second and fourth weeks of radiation.Results: Grade 3+ toxicities were seen only in two patients (6.9%). A significant down staging was seen in 41.4% of all cases and 52.6% of cases with a radiation dose of 50 Gy. Of the patients who had received surgical resection of a tumour, three (11.1%) had no residue pathologically in the specimen and eight (29.6%) had microscopic lesions.Conclusions: These results yielded a high response rate with minimal... |
| Databáze: | OpenAIRE |
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