Trans-ancestral genome-wide association studies of brain imaging phenotypes

Autor: Chunshui Yu, Jilian Fu, Quan Zhang, Jianhua Wang, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhengwei Yao, Wen Qin, Feng Liu, Meng Liang, Sijia Wang, Qiang Xu, Jiayuan Xu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Jiance Li, Wen Shen, Yanwei Miao, Dawei Wang, Junfang Xian, Jia-Hong Gao, Xiaochu Zhang, Kai Xu, Xi-Nian Zuo, Long Jiang Zhang, Zhaoxiang Ye, Jingliang Chen, Mulin Jun Li
Rok vydání: 2022
DOI: 10.21203/rs.3.rs-2047527/v1
Popis: Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and trans-ancestral genome-wide association studies of 3,414 brain imaging phenotypes in 7,058 Chinese and 33,224 European individuals. We identified 37 novel variant-phenotype associations in Chinese-alone analyses and 459 additional novel associations in trans-ancestral meta-analyses under the thresholds of P − 11 for discovery and P
Databáze: OpenAIRE