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Test implantations were carried out on rats in order to investigate the effects of porosity of heterogeneous poly(glycol monomethacrylate) gels on their healingin. The porosity was varied by changing the water content in initial monomeric mixture. The histological analysis has shown that spongy polymers containing 50 and 60% of water in the initial mixture are healed-in similarly to the homogeneous gel by encapsulation with collagen fibrous tissue. In polymers having higher content of water in the initial mixture, i.e. higher porosity, the vessels from the new formed fibrous capsula penetrate into the implant. The higher the porosity, the narrower the capsula and the broader the zone of cellulization and new-formed capillaries, penetrating into the implant. In the case of polymers of higher porosity, giant multinuclear cells are observed in the margin of the implant. The positive Kossa's calcium reaction was found only sporadically on the margin of the implant. |
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