Clinical Evaluation of a Modified 'Oxford T4-by-Column' Method for Serum Thyroxine

Autor:	Norbert W. Tietz, Charles J. Martinez, Marcia Lee
Rok vydání:	1972
Předmět:	medicine.medical_specialty Reproducibility business.industry Biochemistry (medical) Clinical Biochemistry Hospital employees Confidence interval Surgery Standard curve Serum thyroxine medicine Euthyroid Nuclear medicine business Clinical evaluation Normal range
Zdroj:	Clinical Chemistry. 18:422-426
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/18.5.422
Popis:	Three commercially available kits for determining serum thyroxine (T4) by column were evaluated. Results with all were less than satisfactory, but a series of changes in the Oxford method resulted in increased reproducibility, substantially improved recovery, and extended linearity of the standard curve. Results compared well with the thyrometabolic status of patients and normal individuals. The 95% confidence limits for 219 "normal" hospital employees were 2.9-6.2 µg/100 ml. The suggested normal range for 241 clinically euthyroid patients is 2.5-6.0 µg/100 ml. The coefficient of correlation between results of the proposed method and of the PBI method was 0.30; for the T4 by the Murphy—Pattee method it was 0.75.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d61b5e9de26bf88ceccebf4f5d683662 https://doi.org/10.1093/clinchem/18.5.422 Zobrazit plný text záznamu