| Popis: |
Objectives – To evaluate the impact of different dosages of topiramate (TPM) add-on to stable antiepileptic therapy for refractory partial epilepsy in adults. Material and methods – Pooled intention-to-treat analysis of six similarly designed double-blind, placebo-controlled trials, including 481 patients treated with doses of TPM 200, 400, 600 and 800 mg/day, and 265 patients receiving placebo. Results – Seizures were reduced by ≥50% from baseline in 41% of TPM-treated patients and 15% of placebo-treated patients (P |
