Octahydronaphthoquinolizines, a new biologically active tetracyclic ring system

Autor:	David I. Schuster, Bing Cai, Yanping Pan, John C. Dewan, Randall B. Murphy, Donald J. Wink
Rok vydání:	1993
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Drug Discovery Diastereomer Biological activity Nuclear magnetic resonance spectroscopy Acrylonitrile Binding site Ring (chemistry) Biochemistry Pyrrolidine
Zdroj:	Tetrahedron Letters. 34:2067-2070
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60347-7
Popis:	Unsubstituted and methoxy-substituted octahydronaphthoquinolizines, examples of new tetracyclic ring system, have been synthesized in three steps from corresponding 2-tetralones. The various diastereomers of each OHNQ have been separated and characterized by X-ray crystallography and NMR spectroscopy. These compounds have been shown to have activity at selected neurorecepter binding sites.
Databáze:	OpenAIRE
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