Regulation of Cardiac Ion Channels by Cyclic Nucleotide-Dependent Phosphorylation

Autor:	Gordon M. Wahler, Nick Sperelakis
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Cyclic nucleotide chemistry.chemical_compound chemistry Voltage-dependent calcium channel Kinase Second messenger system Phosphorylation Nucleotide Biology Protein kinase A Ion channel Cell biology
DOI:	10.1016/b978-0-12-387738-3.00023-8
Popis:	Ion channels in the heart are regulated by many physiological mechanisms. One of the most important mechanisms is the regulation by cyclic nucleotide protein kinases. Calcium channels in the heart play a central role in excitation–contraction coupling and the physiological modulation of these channels is crucial to the functioning of the heart under differing conditions. Phosphorylation–dephosphorylation reactions regulate the cardiac calcium channel activity. Activation of the cyclic AMP-dependent protein kinase stimulates the channel activity, whereas activation of the cyclic GMP-dependent protein kinase inhibits the channel activity. Both synthesis and degradation of the cyclic nucleotides are regulated by a large number of physiological and pathophysiological first messengers. There is considerable compartmentalization of the components of the cyclic nucleotide pathways and there are significant interactions between the two cyclic nucleotides. The complexities of these two cyclic nucleotide systems allows for fine control of calcium channel activity in the heart.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d5fd0241a1ca40f4b1e2ed1e3b76e77d https://doi.org/10.1016/b978-0-12-387738-3.00023-8 Zobrazit plný text záznamu