DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
| Autor: | Mohd Rahim Nabil Fikri, Mohd Noor Hanisah, Ku Zaifah Norsidah, A. Talib Norlelawati, Abd Rahim Nour El Huda, Abdullah Kartini |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Epigenetics Antipsychotic Risperidone Catechol-O-methyl transferase Positive and Negative Syndrome Scale business.industry General Neuroscience General Medicine Methylation medicine.disease Psychiatry and Mental health 030104 developmental biology Endocrinology Neurology Schizophrenia DNA methylation Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatry and Clinical Neurosciences. 72:266-279 |
| ISSN: | 1323-1316 |
| DOI: | 10.1111/pcn.12622 |
| Popis: | AIM: This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia patients. METHODS: We examined the DNA methylation levels of COMT using genomic DNA from the peripheral blood of schizophrenia patients (n = 138) and healthy control participants (n = 132); all were Malaysian Malays. The extracted DNA was bisulfite converted, and the percentage methylation ratio value was calculated based on the results following a MethyLight protocol analysis. RESULTS: The percentage methylation ratio of COMT was lower in schizophrenia than it was in the healthy controls (P |
| Databáze: | OpenAIRE |
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