Phenotypic and functional analysis of T cell receptor gamma delta-bearing cells isolated from human heart allografts
| Autor: | L M Vaessen, A J Ouwehand, C C Baan, N H Jutte, A H Balk, F H Claas, W Weimar |
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| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 147:846-850 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.147.3.846 |
| Popis: | Endomyocardial biopsies from human heart transplant recipients were investigated with respect to the occurrence of in vivo activated, alloreactive TCR-gamma delta+ cells. More than one year after transplantation, 30% of the biopsy-derived T cell cultures contained TCR-gamma delta+ cells, whereas in the first year after heart transplant in only 8% of the culture TCR-gamma delta+ cells were found. Such an increase of TCR-gamma delta+ cells was not observed in the peripheral blood of the patient. In most biopsy-derived cultures, the gamma delta cells were delta-TCS1+. No donor-specific cytotoxic activity could be demonstrated for TCR-gamma delta+ cells tested, whereas non-MHC-restricted cytotoxicity was found in several cultures. The occurrence of nonalloreactive TCR-gamma delta+ cells late after transplantation, when acute cellular rejection episodes are rare, suggests a role in the down-regulation of the allo-Ir. |
| Databáze: | OpenAIRE |
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