Analysis of 2 Antiapoptotic Factors in Gliomas

Autor: Jerónimo Forteza, J. M. Suarez-Peñaranda, M. Vazquez-Salvado, F. Barros, C. Rodriguez-Pereira, M. J. Sobrido
Rok vydání: 2001
Předmět:
Zdroj: Archives of Pathology & Laboratory Medicine. 125:218-223
ISSN: 1543-2165
0003-9985
DOI: 10.5858/2001-125-0218-aoafig
Popis: Background.—p53 mutations and immunoreactivity have been described in human gliomas. During the past few years, some authors have found bcl-2 overexpression in astrocytomas, although their correlation with histological grade is a matter of disagreement. A relation between bcl-2 overexpression and p53 immunoreactivity has also been suggested. Objectives.—To analyze the frequency of presentation of bcl-2 and p53, their clinicopathologic implications, and their possible coexpression. Methods.—We studied p53 and bcl-2 with immunohistochemical and molecular methods in 61 gliomas (including 21 astrocytomas, 9 anaplastic astrocytomas, 29 glioblastomas, 1 oligodendroglioma, and 1 mixed glioma). Results.—We discovered a high level of bcl-2 overexpression (57%). Overexpression of bcl-2 can be an early event in gliomas tumorigenesis, although no correlation was found with any of the clinicopathologic parameters studied. p53 mutations were present in a small proportion of gliomas (17%). p53 immunoreactivity was present in 34 cases (57%), and it was related to histological grade and a supratentorial location. A high percentage of tumors (26 cases, 42%) presented p53 immunoreactivity without p53 mutations. Conclusions.—Since there was no relation between bcl-2 overexpression and p53 mutations or p53 immunoreactivity, both factors may not act together in the genesis and evolution of gliomas.
Databáze: OpenAIRE
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