Pharmacokinetics of Intravenously Administered Nicomorphine and its Metabolites and Glucuronide Conjugates in Surgical Patients

Autor:	R. Dirksen, L. H. D. J. Booij, P. M. Koopman-Kimenai, T. B. Vree
Rok vydání:	1994
Předmět:	business.industry Pharmacology toxicology General Medicine Pharmacology Nicomorphine Pharmacokinetics medicine Morphine Pharmacology (medical) Glucuronide business Surgical patients medicine.drug Conjugate
Zdroj:	Drug Investigation. 7:63-73
ISSN:	1179-1918 0114-2402
DOI:	10.1007/bf03257401
Popis:	After intravenous administration of 3, 6-dinicotinoylmorphine (nicomorphine) 30, 20 and 10mg to patients undergoing surgery, this agent is rapidly metabolised into the metabolites 6-mononicotinoylmorphine (6MNM) and morphine. The elimination half-lives are 1 minute for nicomorphine, 13 minutes for 6MNM and 120 minutes for morphine. Morphine is subsequently metabolised into morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). The half-life of these 2 glucuronide conjugates is similar, about 225 minutes. A glucuronide conjugate of 6MNM was not detected. The area under the serum concentration-time curve of nicomorphine and its metabolites is linearly related to the dose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d5e7cdc72212976aca9a1e6b42dc3678 https://doi.org/10.1007/bf03257401 Zobrazit plný text záznamu Full text from SpringerLink